Informatics Publishing Limited

Mohsen Younus ¹, Aasif Younus ², Akshay Kumar ¹

Affiliations
1 Vitalife Laboratories Ltd, Gurgaon, Haryana-(122001), IN
2 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh-(284001), IN

Abstract

The crude methanolic extract of the seeds of Celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and antialzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In DPPH radical scavenging assay, the EtOAc fraction showed the highest activity with a IC50 value of 25.92±1.02 μg/ml whereas aqueous fractions had no activity at all within the tested concentration. Scavenging of the authentic ONOO- system, all extract/fractions showed good activity and among them, EtOAc fraction had the highest activity with a IC50 value of 15.79±0.18 μg/ml. EtOAc fraction also showed significant (p<0.001) inhibitory activity against the total ROS generation which was almost similar with that of the positive control Trolox (IC50 16.79±0.19 μg/ml). All extract/fractions exhibited statistically significant (p<0.001) cholinesterases (ChEs) inhibitory effects with IC50 values ranging between 134.7-227.5 μg/ml for AChE and 209.6-562.1 μg/ml for BChE.

Keywords

Anti-Alzheimer, Antioxidant, Cholinesterase, Celastrus Paniculatus, ROS

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Ekambir Sidhu ¹, Akshay Kumar ¹, Amarveer Singh ¹

Affiliations
1 Department of Electronics and Communication Engineering, Punjabi University, Patiala, IN

Abstract

This paper illustrates the design and performance analysis of proposed stacked horse-shoe shaped micro strip patch antenna. In the proposed stacked antenna design, a rigid substrate having thickness 1.57mm and flexible substrate having thickness 0.2mm has been stacked. In the proposed antenna design, there are total two layers of substrates, where the flexible substrate has been placed on the upper surface of rigid substrate. The rigid and flexible substrates employed in the proposed antenna design are of duroid material having dielectric constant of 2.2. In the proposed antenna design, the rigid substrate has ahorse-shoe shaped patch on the upper surface and a ground on the bottom surface. The performance of the proposed antenna design has been analysed in terms of resonant frequency, impedance bandwidth, VSWR, impedance, return loss, gain and directivity. The proposed antenna design has resonant frequencies at 2.18 GHz and 5.2 GHz having return loss of -22.496dBand -55.012dB, respectively. The proposed design has two operating bands having operating frequency range of 2.02GHz-2.43GHz and 3.22GHz-6.13GHz. The proposed antenna has been designed and simulated using CST microwave studio 2014. The proposed antenna design can be used for WLAN, WiMAX and IMT applications.

Keywords

Dual Band, Duroid, Horse-Shoe, Stacking.

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Akshay Kumar ¹, Vishal Parashar ¹

Affiliations
1 Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal - 462003, Madhya Pradesh, IN

Abstract

Objectives: In this paper, the effect of reinforcement content, load and speed on the wear behaviour of Cu/SiC metal matrix composite are investigated using design of experiment. Methods: A statistical model is proposed to find the significant factor which affects the wear resistance properties of the prepared composite material. Three samples of composites were fabricated using different SiC content by stir casting. The wear behaviour of composites was evaluated for a variety of load and sliding speed at ambient temperature. Findings: It is found with the increase in SiC content the rate of wear of the composite decrease while with increase in load the wear rate increased. Also with increase of sliding speed wear rate is increased. Among the three variable parameters chosen for the study viz. reinforcement content, load and sliding speed, the load is the mainly prominent factor that affects the wear resistance of the composite. Applications/Improvements: This study can be enhanced further by using different reinforcement’s combinations and parameters. Also the wear tests can be performed at elevated temperatures.

Keywords

DOE, Metal Matrix Composites, Wear.

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Akshay Kumar ¹, Anupam Kumar Ranjan ¹, Praveen Aggarwal ¹

Affiliations
1 Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, IN

Abstract

Amitraz is a veterinary pesticide commonly used for killing lice in dogs and cattle. Amitraz poisoning is reported from some areas of the world. It is important to recognise this particular poisoning and differentiate it from organophosphate poisoning (OPC). We present here a case of a 19-year-old girl who presented to us with all the typical symptoms of Amitraz poisoning and was effectively managed at our centre.

Keywords

Amitraz Poisoning, Organophosphate.

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Akshay Kumar ¹, Gagandeep Singh Mavi ¹

Affiliations
1 Department of Mechanical Engineering, Chandigarh University, Gharuan - 140413, Punjab, IN

Abstract

Objectives: The study is conducted to perform the modelling and structural analysis of engine mounting bracket and also examine the vibration isolation using FFT analyzer. Methods/ Statistical analysis: Modelling and analysis of the engine mounting bracket is carried out using solid works software. Static and modal analysis are performed to check the stress, deflection and effect of natural frequencies under loading conditions. The experimentation is also performed using FFT analyzer to check the effect of vibrations on the bracket in horizontal and vertical position. Findings: Analysis was carried out for different materials like natural rubber, neoprene, and silicon rubber. On comparing the results, the silicon rubber found better material as compare to other materials due to its low stress and deflection value and better frequency values. The experiment results shown that in the horizontal position the vibration were less than the vertical position. Application/ Improvements: Silicon rubber is considered better material for engine mounting bracket for vibration damping. This approach also helps us to find out the weak area in early design phase.

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Alok Ranjan ¹, Aishwarya Sahu ¹, Akansha Yadav ¹, Alka Payasi ¹, Akash Jaiswal ¹, Akshay Kumar ¹, Akash Sahu ¹, Ashwani Jangde ¹, Chandrashekhar Nayak ¹, Dev Kumar ¹, Harshita Yarda ¹, Mitali Sahu ¹, Nokesh Sahu ¹, Rajesh Patel ¹, Nisha Nair ¹, Mukta Agrawal ¹, Ajazuddin ¹, D. K. Tripathi ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN

Abstract

The transdermal drug delivery systems (TDDS) are drug delivery system that gives rapid, the immediate therapeutic effect of the drug across the patient’s skin and its different layers. They are also called as patches. More than 75% of the drugs, now a day’s, are taken orally and are not very much effective. To overcome these problems, the transdermal drug delivery system has been evolved. The advantage of transdermal patches is that they deliver the drugs for better systemic effects at a controlled and a predetermined rate. This drug delivery system also endorses the controlled release of drug medicament into the skin of the patients. The chief aim of this drug delivery system is to deliver the drug contents into the systemic circulation through the permeation of skin at a predetermined rate. This article is an overview of different types of transdermal patches, their various method of preparation as well as their various physicochemical evaluation methods. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

TDDS, Systemic Circulation, Transdermal Patches, Systemic Effects, Drug Medicament, Novel Drug Delivery System.

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